Energy landscape analysis of health checkup data clarified multiple pathways to diabetes development in obese and non-obese subjects
We demonstrated that ELA could indicate different pathways of diabetes development in obese and non-obese individuals in a data-driven manner. These insights could inform more targeted diabetes prevention measures, such as reducing visceral fat in obese individuals and protecting beta-cells in non-obese individuals.
Authors
- Daisuke Chujo (ORCID: https://orcid.org/0000-0001-7727-6310)
- Masataka Shikata (ORCID: https://orcid.org/0000-0001-9314-6313)
- Makoto Kadowaki (ORCID: https://orcid.org/0000-0002-5945-9380)
- Takashi Yamagami
- Takayuki Haruki (ORCID: https://orcid.org/0000-0003-2718-0972)
- Yoshiki Nagata (ORCID: https://orcid.org/0000-0002-0217-697X)
- Shiho Fujisaka (ORCID: https://orcid.org/0000-0003-0554-9003)
- Iori Kimura
- Kazuyuki Tobe
- Makito Oku (ORCID: https://orcid.org/0000-0002-0282-2361)
- Keiichi Ueda (ORCID: https://orcid.org/0000-0003-3078-1162)
- Ryô Itô (ORCID: https://orcid.org/0000-0002-5958-1132)
- Minoru Iwata (ORCID: https://orcid.org/0009-0008-8438-6997)
- Shigeru Saito
- Tsuyoshi Teramoto
Institutions
- Hokuriku Electric Power Company (Japan) (JP)
- Toyama University Hospital (JP)
- University of Toyama (JP)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-05-06
- DOI
- https://doi.org/10.3389/fendo.2025.1576431
- Citations
- 3
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 3.49
Funders
- Japan Science and Technology Agency
- Moonshot Research and Development Program