A proteotranscriptomic approach to dissect the molecular landscape of human retinoblastoma
CD44+ and high-c-Myc-expressing tumor cells may represent cancer stem cells with possible involvement in metastasis, warranting further validation. Our multilayered approach could pave the way for enhanced molecular assessments and novel targeted therapies for human retinoblastoma.
Authors
- Stefan Tholen (ORCID: https://orcid.org/0009-0008-4746-2356)
- Clemens AK Lange
- Claudia Auw‐Haedrich (ORCID: https://orcid.org/0000-0002-3408-341X)
- Ira Godbole
- Günther Schlunck (ORCID: https://orcid.org/0000-0002-0355-7766)
- Julian Wolf (ORCID: https://orcid.org/0000-0002-3470-9697)
- Rozina Ida Hajdú
- Thomas Reinhard (ORCID: https://orcid.org/0000-0002-4937-6936)
- Bertram Bengsch (ORCID: https://orcid.org/0000-0003-2552-740X)
- Hansjürgen Agostini (ORCID: https://orcid.org/0000-0002-0331-1109)
- Stefaniya Boneva (ORCID: https://orcid.org/0000-0002-9811-2160)
- Oliver Schilling (ORCID: https://orcid.org/0000-0001-7678-7653)
- Wolf A. Lagrèze (ORCID: https://orcid.org/0000-0002-3558-5905)
- Lucas Stürzbecher
Institutions
- University of Freiburg (DE)
- University Medical Center Freiburg (DE)
- St. Franziskus Hospital (DE)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-05-06
- DOI
- https://doi.org/10.3389/fonc.2025.1571702
- Primary Topic
- Ubiquitin and proteasome pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Albert-Ludwigs-Universität Freiburg