The Pregnane-X receptor regulates steroid synthesis in mouse Leydig cells
Overall, these results support the involvement of PXR in the regulation of testosterone homeostasis in mouse Leydig cells and open new avenues of research into the involvement of this receptor in the deleterious effects of certain endocrine disruptors on the steroidogenic activity of Leydig cells.
Authors
- Angélique De Haze
- Claude Beaudoin (ORCID: https://orcid.org/0000-0002-4710-0610)
- David H. Volle (ORCID: https://orcid.org/0000-0003-0843-0550)
- Emmanuelle Martinot
- Hélène Holota
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Clermont Université (FR)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-05-06
- DOI
- https://doi.org/10.3389/fendo.2024.1430781
- Citations
- 1
- Primary Topic
- Estrogen and related hormone effects
- Type
- article
- Field-Weighted Citation Impact
- 1.82
Funders
- Agence Nationale de la Recherche
- Institut National de la Santé et de la Recherche Médicale
- Ligue Contre le Cancer
- Centre National de la Recherche Scientifique
- Centre National pour la Recherche Scientifique et Technique