Osteopontin regulates right ventricular failure through integrin ανβ3/PERK/CHOP-dependent inflammatory and apoptotic pathways
These findings identify OPN as a crucial mediator of RVF pathogenesis through the regulation of inflammatory and apoptotic pathways, establishing its potential as a promising therapeutic target.
Authors
- Yonghao Hou
- Guangmin Xi
- Jingui Yu
- Yu Bai (ORCID: https://orcid.org/0000-0002-8237-9514)
- Jianbo Wu (ORCID: https://orcid.org/0000-0002-9893-9096)
- Peng Zhang (ORCID: https://orcid.org/0000-0002-4191-1068)
- Kai Li (ORCID: https://orcid.org/0000-0003-4601-3627)
- Xuyang Wang (ORCID: https://orcid.org/0000-0003-2383-9709)
- Kangping Lu
- Xiaomei Yang (ORCID: https://orcid.org/0000-0002-4081-4207)
- Zihua Liu (ORCID: https://orcid.org/0000-0003-3891-5700)
- Qiming Deng
Institutions
- Shandong University (CN)
- Capital Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Qilu Normal University (CN)
- Second Hospital of Shandong University (CN)
- Shandong Provincial Hospital (CN)
- Beijing Anzhen Hospital (CN)
- Ministry of Education (TH)
- Shandong Provincial QianFoShan Hospital (CN)
- Qilu Hospital of Shandong University (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-06
- DOI
- https://doi.org/10.3389/fimmu.2025.1569210
- Citations
- 1
- Primary Topic
- Endoplasmic Reticulum Stress and Disease
- Type
- article
- Field-Weighted Citation Impact
- 1.15