Neutrophil/lymphocyte ratio: a potential biomarker in patients with head and neck squamous cell carcinoma treated with immune checkpoint inhibitors
Basal NLR value lower than the cut-off of 4 is independently associated with better OS, PFS and ORR in patients with R/M HNSCC treated with immunotherapy, in first- or second- line.
Authors
- Marianna Caterino (ORCID: https://orcid.org/0000-0001-6035-8213)
- Guido Giordano (ORCID: https://orcid.org/0000-0002-9310-1075)
- Andrea Pietro Sponghini
- Davide Ciardiello
- Liliana Montella (ORCID: https://orcid.org/0000-0002-6397-086X)
- Francesca Vignani (ORCID: https://orcid.org/0000-0002-0123-0292)
- Mario Pirozzi
- Morena Fasano (ORCID: https://orcid.org/0000-0003-0782-8778)
- Vincenzo Famiglietti (ORCID: https://orcid.org/0000-0002-5959-3838)
- Fortunato Ciardiello (ORCID: https://orcid.org/0000-0002-4661-5540)
- Aurora Mirabile (ORCID: https://orcid.org/0000-0002-1475-0940)
- Giorgio Lo Giudice (ORCID: https://orcid.org/0000-0001-9944-1073)
- Francesco Perri (ORCID: https://orcid.org/0000-0001-8158-7509)
- Stefano Farese
- Raffaele Addeo (ORCID: https://orcid.org/0000-0001-9197-8060)
- Sara Di Lorenzo (ORCID: https://orcid.org/0009-0007-0218-6258)
- Vincenzo Ricci (ORCID: https://orcid.org/0000-0002-8779-4792)
- Vincenzo Damiano
Institutions
- University of Foggia (IT)
- University of Messina (IT)
- Università degli Studi del Piemonte Orientale “Amedeo Avogadro” (IT)
- Vita-Salute San Raffaele University (IT)
- Università degli Studi di Enna Kore (IT)
- Azienda Ospedaliero Universitaria Maggiore della Carita (IT)
- A. O. Ordine Mauriziano di Torino (IT)
- Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale" (IT)
- Azienda Ospedaliera Ospedale Maggiore (IT)
- European Institute of Oncology (IT)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-05-06
- DOI
- https://doi.org/10.3389/fonc.2025.1557652
- Citations
- 2
- Primary Topic
- Inflammatory Biomarkers in Disease Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 2.09