COP1 drives renal cell carcinoma progression by targeting ACSL4 for ubiquitin-mediated degradation and inhibiting ferroptosis
Our study establishes COP1 as a critical driver of RCC progression by suppressing ferroptosis through ubiquitin-mediated degradation of ACSL4, thereby providing a novel theoretical foundation for targeted therapeutic strategies in RCC.
Authors
- Bo Peng (ORCID: https://orcid.org/0000-0003-0416-9076)
- Lei Jiang (ORCID: https://orcid.org/0000-0002-5143-9262)
- Feng Qi (ORCID: https://orcid.org/0000-0003-1061-7058)
- Yuxiao Zheng (ORCID: https://orcid.org/0000-0002-4305-4223)
Institutions
- Jiangsu Cancer Hospital (CN)
- Qujiang People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-05-06
- DOI
- https://doi.org/10.3389/fonc.2025.1570727
- Citations
- 1
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.52