Integrative single-cell and spatial transcriptomics analysis reveals MDK-NCL pathway’s role in shaping the immunosuppressive environment of lung adenocarcinoma
Our findings reveal that LUAD cells use the MDK-NCL signaling pathway to shape the TME, suppressing immune activity and promoting malignancy in epithelial cells. This study highlights the MDK-NCL axis as a potential therapeutic target for LUAD, particularly for patients with high MDK-NCL expression.
Authors
- Yu Fu (ORCID: https://orcid.org/0000-0003-4972-0626)
- Ran Xu (ORCID: https://orcid.org/0000-0002-7051-8564)
- Xiran Zhang
- Xiaolu Mao (ORCID: https://orcid.org/0000-0001-9007-1950)
- Yupei Zhao (ORCID: https://orcid.org/0000-0001-7081-2299)
- Song Li (ORCID: https://orcid.org/0000-0003-1658-949X)
Institutions
- China Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-06
- DOI
- https://doi.org/10.3389/fimmu.2025.1546382
- Citations
- 9
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 7.25