Acute ischaemia and gap junction modulation modify propagation patterns across Purkinje-myocardial junctions
Normally-quiescent PMJs can become active in the context of gap junction uncoupling during acute ischaemia. Pharmacological gap junction modulation may alter propagation patterns across PMJs and may be used as a therapeutic strategy for Purkinje system associated arrhythmias.
Authors
- Igor R. Efimov (ORCID: https://orcid.org/0000-0002-1483-5039)
- Elham Behradfar
- Richard J. Jabbour (ORCID: https://orcid.org/0000-0002-9028-2413)
- Michael T Debney
- Adam Hartley (ORCID: https://orcid.org/0000-0003-1431-2200)
- Anders Nygren (ORCID: https://orcid.org/0000-0003-0810-7016)
- Fu Siong Ng (ORCID: https://orcid.org/0000-0002-8681-4368)
- Mélèze Hocini (ORCID: https://orcid.org/0000-0002-7957-8766)
- Nicholas S. Peters (ORCID: https://orcid.org/0000-0002-3581-8078)
- Edward J. Vigmond
Institutions
- Northwestern University (US)
- Université de Bordeaux (FR)
- University of Calgary (CA)
- Electrophysiology and Heart Modeling Institute (FR)
- McCormick (United States) (US)
- Institut de Mathématiques de Bordeaux (FR)
- Imperial College London (GB)
Publication Details
- Journal
- Frontiers in Physiology
- Published
- 2025-05-06
- DOI
- https://doi.org/10.3389/fphys.2025.1540400
- Citations
- 3
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 4.16
Funders
- British Heart Foundation
- Agence Nationale de la Recherche
- Fondation Leducq
- National Institutes of Health