Identification of Novel Selective Transient Receptor Potential Vanilloid 4 (TRPV4) Agonists
Our study provides new insight into the role of TRPV4 in pain and itch sensation and introduces LM0038, the most potent agonist, as a novel alternative to GSK101. With enhanced biological activity, it may serve as a valuable tool for studying TRPV4 function.
Authors
- Meiying Liu (ORCID: https://orcid.org/0000-0003-4916-4199)
- Yixin Zhang (ORCID: https://orcid.org/0000-0002-3240-6174)
- Heng Xu (ORCID: https://orcid.org/0000-0003-1307-4896)
- Yuxin Jia (ORCID: https://orcid.org/0009-0002-1719-8220)
Institutions
- Shanghai Jiao Tong University (CN)
- Capital Medical University (CN)
- Chinese Academy of Sciences (CN)
- Shanghai Ninth People's Hospital (CN)
- Shanghai Institute of Materia Medica (CN)
- Beijing Children’s Hospital (CN)
Publication Details
- Journal
- Current Pharmaceutical Design
- Published
- 2025-05-06
- DOI
- https://doi.org/10.2174/0113816128381222250428094819
- Citations
- 1
- Primary Topic
- Exercise and Physiological Responses
- Type
- article
- Field-Weighted Citation Impact
- 1.03