Baicalin Inhibits Lung Cancer Cell Proliferation and Migration via ALOX12-Mediated Ferroptosis
Baicalin significantly upregulated ALOX12 expression, promoted ferroptosis, and inhibited the proliferation and migration of A549 lung cancer cells. This finding provides evidence for the potential use of baicalin as a therapeutic agent for lung cancer and highlights the importance of ALOX12 in lung cancer treatment strategies.
Authors
- Wujin Chen (ORCID: https://orcid.org/0000-0003-0560-8026)
- Xuan Wang (ORCID: https://orcid.org/0000-0002-1542-3642)
- Zhenbo Geng
- Biyin Chen
- Hanqing Zhao
- Jiumao Lin (ORCID: https://orcid.org/0000-0001-9770-0641)
- Yanshan Jin (ORCID: https://orcid.org/0000-0003-0124-6849)
- Jinyu Wen (ORCID: https://orcid.org/0000-0002-0288-727X)
- Hui Hua (ORCID: https://orcid.org/0000-0002-8229-5492)
- Xiaohua Yan
- Wenzheng Fang (ORCID: https://orcid.org/0000-0003-2871-8367)
Institutions
- Fujian University of Traditional Chinese Medicine (CN)
- Fujian Medical University (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Fujian Provincial Hospital (CN)
- Fuzhou University (CN)
- Fujian University of Technology (CN)
Publication Details
- Journal
- Anti-Cancer Agents in Medicinal Chemistry
- Published
- 2025-05-06
- DOI
- https://doi.org/10.2174/0118715206342238250428115441
- Citations
- 1
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.52