Data-independent Acquisition Mass Spectrometry Reveals Exosomal LAMC1 as a Key Determinant of Lung Adenocarcinoma Radiosensitivity, Independent of EGFR Mutation
LAMC1 serves as a critical functional determinant of radiotherapy resistance in LUAD. Its dynamic changes in exosomes demonstrate potential for predicting radiotherapy response, suggesting clinical utility for radiosensitivity assessment and personalized radiotherapy guidance.
Authors
- Hao Jiang (ORCID: https://orcid.org/0000-0003-2008-6166)
- Xiaolong Fu (ORCID: https://orcid.org/0000-0001-8127-3884)
- Li Sun (ORCID: https://orcid.org/0000-0002-4421-7207)
- Wen Feng
- Chang Jiang (ORCID: https://orcid.org/0000-0002-4878-3054)
- Yi‐Ting Wang (ORCID: https://orcid.org/0000-0003-2008-4435)
- Qian Sun (ORCID: https://orcid.org/0009-0005-6028-8661)
- Xueru Zhu
Institutions
- Bengbu Medical College (CN)
- Shanghai Jiao Tong University (CN)
- Shanghai Chest Hospital (CN)
Publication Details
- Journal
- Current Pharmaceutical Design
- Published
- 2025-05-06
- DOI
- https://doi.org/10.2174/0113816128392494250430173324
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00