Therapeutic potential of repaglinide-embedded chitosan hydrogel in promoting wound healing
Repaglinide-loaded chitosan-based hydrogels, particularly Hy-R3%, represent a promising new therapeutic approach for wound healing. The formulation demonstrated enhanced physicochemical and biological properties, including rapid wound closure and improved tissue regeneration. These findings suggest that repaglinide can be repurposed for wound healing applications, particularly for chronic and diabetic wounds, and lay the foundation for future studies on its broader regenerative potential.
Authors
- Mohammed Merza (ORCID: https://orcid.org/0000-0002-3899-2231)
- Ahmed Hjazi (ORCID: https://orcid.org/0000-0002-1129-6930)
- Narges Fereydouni (ORCID: https://orcid.org/0000-0002-1885-1669)
- Subhashree Ray (ORCID: https://orcid.org/0000-0003-0059-7014)
- E. M. S. Azzam (ORCID: https://orcid.org/0000-0003-3696-9596)
- Upinder Singh (ORCID: https://orcid.org/0000-0003-0630-0306)
- Chou‐Yi Hsu (ORCID: https://orcid.org/0000-0001-7105-1161)
- Marwah Suliman Maashi (ORCID: https://orcid.org/0000-0003-4034-4011)
- Hawbash M. Rahim (ORCID: https://orcid.org/0000-0002-0686-3793)
- Kapil Ghai
Institutions
- Jain University (IN)
- Prince Sattam Bin Abdulaziz University (SA)
- Hawler Medical University (IQ)
- King Abdulaziz University (SA)
- Siksha O Anusandhan University (IN)
- University of Al Maarif (IQ)
- Institute of Medical Sciences and Sum Hospital (IN)
- King Fahad Hospital Jeddah (SA)
- Fasa University of Medical Sciences (IR)
- Chia Nan University of Pharmacy and Science (TW)
- Graphic Era University (IN)
- Chitkara University (IN)
- Tishk International University (IQ)
Publication Details
- Journal
- Regenerative Therapy
- Published
- 2025-05-06
- DOI
- https://doi.org/10.1016/j.reth.2025.04.021
- Citations
- 2
- Primary Topic
- Wound Healing and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.05
Funders
- Fasa University of Medical Sciences