Regulation of Nrf2/<scp>GPX4</scp> Signaling Pathway by Hyperbaric Oxygen Protects Against Depressive Behavior and Cognitive Impairment in a Spinal Cord Injury Rat Model
These findings highlight ferroptosis as a key pathological mechanism in SCI-induced hippocampal damage and suggest that HBO therapy alleviates depressive-like behavior and cognitive impairment by targeting the Nrf2/GPX4 pathway. This study provides new insights into the therapeutic potential of HBO in managing SCI-related neuropsychiatric dysfunction.
Authors
- Fuxiang Chen (ORCID: https://orcid.org/0000-0002-4093-2676)
- Meng Shi (ORCID: https://orcid.org/0000-0002-5412-7977)
- Shumin Ye (ORCID: https://orcid.org/0009-0003-4188-3954)
- Peng Chen (ORCID: https://orcid.org/0000-0001-7931-3349)
- Xueyan Liu (ORCID: https://orcid.org/0000-0002-7229-2810)
- Xinyi Yang (ORCID: https://orcid.org/0000-0002-0171-5003)
- Chenlu Li (ORCID: https://orcid.org/0000-0002-9268-9217)
- Fang Liu (ORCID: https://orcid.org/0009-0006-8173-5157)
- Chaoxian Dai
- Zhongyue Wu (ORCID: https://orcid.org/0009-0003-8414-4553)
Institutions
- Fujian Medical University (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1111/cns.70421
- Citations
- 9
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 7.58
Funders
- Fujian Provincial Health Technology Project