Non-coding RNAs PROX1-AS1 and miR-647: Potential Interaction and Prognostic Value in Gastric Cancer

We have demonstrated a negative correlation between PROX1-AS1 and miR-647 in both GC tissues and the cancer cell lines. In addition, expression of both ncRNAs was associated with the primary tumor size. Therefore, these ncRNAs might have potential prognostic value.

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Journal
Current Molecular Medicine
Published
2025-05-05
DOI
https://doi.org/10.2174/0115665240343937250426134726
Primary Topic
Cancer-related molecular mechanisms research
Type
article
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article

Non-coding RNAs PROX1-AS1 and miR-647: Potential Interaction and Prognostic Value in Gastric Cancer

М. В. Немцова, Alexey I. Kalinkin, Artem D. Molchanov, E. A. Alekseeva et al.
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Non-coding RNAs PROX1-AS1 and miR-647: Potential Interaction and Prognostic Value in Gastric Cancer

М. В. Немцова, Alexey I. Kalinkin, Artem D. Molchanov, E. A. Alekseeva, Neonila V. Gorokhovets, A.E. Kiseleva, Ivan V. Rodionov, Ekaterina A. Vetchinkina, Irina V. Bure, E I Kuznetsova
article en

Abstract

We have demonstrated a negative correlation between PROX1-AS1 and miR-647 in both GC tissues and the cancer cell lines. In addition, expression of both ncRNAs was associated with the primary tumor size. Therefore, these ncRNAs might have potential prognostic value.

Current Molecular MedicineVol. 25
Sechenov University (RU), Russian Medical Academy of Continuous Professional Education (RU), Research Centre for Medical Genetics (RU)
Good health and well-being
Openalex Percentile: Top 87%
Cancer-related molecular mechanisms research
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