The Number and Size of Glomeruli and Podocytes in the Aging Human Kidney
Aging is a biological process involving morphological and functional changes in all organs, including the kidneys. As a functional phenotype of the aging kidney, glomerular filtration rate decreases with age. Studies examining autopsy kidneys and living donor kidneys have shown that the number of non-sclerotic glomeruli per kidney decreases with age.1,2 The number of podocytes per glomerulus also decreases with age and can lead to proteinuria and glomerulosclerosis.3
Authors
- Akira Shimizu (ORCID: https://orcid.org/0000-0002-5015-1697)
- Takaya Sasaki (ORCID: https://orcid.org/0000-0001-9525-2638)
- Kotaro Haruhara (ORCID: https://orcid.org/0000-0003-1918-0390)
- John F. Bertram (ORCID: https://orcid.org/0000-0001-5863-6464)
- Nobuo Tsuboi (ORCID: https://orcid.org/0000-0002-5407-5265)
- Go Kanzaki
- Yusuke Okabayashi (ORCID: https://orcid.org/0000-0001-7150-6947)
- Takashi Yokoo
- Eisuke Kubo (ORCID: https://orcid.org/0009-0008-9491-5653)
Institutions
- Jikei University School of Medicine (JP)
- Monash University (AU)
- Nippon Medical School (JP)
Publication Details
- Journal
- Kidney International Reports
- Published
- 2025-05-06
- DOI
- https://doi.org/10.1016/j.ekir.2025.04.054
- Primary Topic
- Renal Diseases and Glomerulopathies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Society for the Promotion of Science