Genomic and transcriptomic landscapes of metastatic neuroendocrine neoplasms from distinct primary sites and their clinical implications
Neuroendocrine neoplasms (NENs) encompass a highly heterogeneous group of neoplasms with varying prognoses and molecular alterations. Molecular profiling studies have furthered our understanding of NENs, but the majority of previous studies have focused on primary tumors and on mutational landscapes using DNA sequencing data. Here, we describe the genomic and transcriptomic landscapes of 28 metastatic NENs across different primary anatomical sites (PASs) and their potential clinical implications. Although our cohort is small, our analyses provide further insights on the molecular commonalities and distinctions between metastatic NENs of different PASs. Comparison to several reference transcriptome data sets revealed that despite considerable whole genome and transcriptome variability in NENs, the metastatic NENs are still more like each other than other cancer types. Our study also highlights the potential utility of NEN transcriptome data for molecular classification and clinical decision making.
Authors
- Emily Leung (ORCID: https://orcid.org/0000-0001-6593-4865)
- Sharon M. Gorski (ORCID: https://orcid.org/0000-0002-3821-8289)
- Xiaolan Feng (ORCID: https://orcid.org/0000-0002-7333-8198)
- Kevin Yang (ORCID: https://orcid.org/0000-0001-6337-6206)
- Kathleen Wee
- Jonathan M. Loree (ORCID: https://orcid.org/0000-0001-8189-2132)
- Marco A. Marra (ORCID: https://orcid.org/0000-0001-7146-7175)
- Janessa Laskin (ORCID: https://orcid.org/0000-0002-0161-9329)
- Chen Zhou (ORCID: https://orcid.org/0000-0002-7659-8083)
- David F. Schaeffer (ORCID: https://orcid.org/0000-0002-7341-1308)
Institutions
- Island Health (CA)
- BC Cancer Agency (CA)
- University of British Columbia (CA)
- Spinal Cord Injury BC (CA)
- Vancouver General Hospital (CA)
- Canada's Michael Smith Genome Sciences Centre (CA)
- Pancreas Centre (Canada) (CA)
Publication Details
- Journal
- Scientific Reports
- Published
- 2025-05-06
- DOI
- https://doi.org/10.1038/s41598-025-00549-7
- Primary Topic
- Neuroendocrine Tumor Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Neuroendocrine Tumor Research Foundation
- Canada's Michael Smith Genome Sciences Centre
- Canadian Cancer Society
- Michael Smith Health Research BC
- Genome British Columbia
- BC Cancer Foundation
- National Human Genome Research Institute
- National Cancer Institute