Racemization of Cross-Chain Bridging Cryptands: Effects of Linker Combination on Racemization Rate
We synthesized three 28-membered chiral cross-chain bridging cryptands ([3.3.6], [4.4.5], and [5.5.4]) with three different linker combinations. After the separation of their enantiomers, the racemization behavior of the cryptands was evaluated by chiral high-performance liquid chromatography. As the number of ethylene glycol units in the two cross-chain linkages increased, the racemization reaction proceeded slowly.
Authors
- Shinobu Miyagawa
- Takashi Maruyama (ORCID: https://orcid.org/0000-0001-7959-8831)
- Yuji Tokunaga (ORCID: https://orcid.org/0000-0002-4183-7320)
- S Niimi
Institutions
- University of Fukui (JP)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-05-06
- DOI
- https://doi.org/10.1021/acs.orglett.5c01161
- Primary Topic
- Chemical Synthesis and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Society for the Promotion of Science