Mechanochemical Synthesis of Indene-Containing Spirolactones via Tf<sub>2</sub>O-Promoted Cascade Cyclization of 2-Benzoylbenzoic Acids with Arylalkynes
The Tf<sub>2</sub>O-promoted cascade cyclization of 2-benzoylbenzoic acids with arylalkynes was achieved under solvent-free ball-milling conditions. This process renders rapid entry to the rare indene-containing spirolactones via intramolecular cyclization of 2-benzoylbenzoic acids and subsequent annulation with arylalkynes, which resulted in one C-O and two C-C bond formations. As the reactions utilize easily available starting materials and proceed in the absence of organic solvents, the present protocol constitutes an expedient and environmentally friendly access to indene-containing spirolactones.
Authors
- Guan‐Wu Wang (ORCID: https://orcid.org/0000-0001-9287-532X)
- Zheng‐Chun Yin (ORCID: https://orcid.org/0000-0002-0311-6688)
- L. Li (ORCID: https://orcid.org/0000-0001-6411-6107)
- Zhiying Zhang (ORCID: https://orcid.org/0000-0001-6012-0889)
- Xu-Ling Xia
Institutions
- University of Science and Technology of China (CN)
- Hefei Normal University (CN)
- State Key Laboratory of Applied Organic Chemistry
- Anhui Normal University (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-05-06
- DOI
- https://doi.org/10.1021/acs.orglett.5c01361
- Citations
- 1
- Primary Topic
- Chemical synthesis and alkaloids
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Natural Science Foundation of China
- Hefei Normal University