Transcriptomic Features of Recurrence Rates in Idiopathic Subglottic Stenosis
Transcriptomic profiling suggests that lower recurrence rates in iSGS are associated with retention of respiratory cilia, while adaptive immune responses and increased extracellular matrix deposition are present in those with higher recurrence rates. These results hold promise for the development of prognostic markers and identification of therapeutic targets for iSGS.
Authors
- Peter YF. Zeng (ORCID: https://orcid.org/0000-0002-6818-8236)
- Wen Rui (ORCID: https://orcid.org/0000-0002-1616-0469)
- Harrison Pan (ORCID: https://orcid.org/0009-0003-7472-3199)
- Amir H. Karimi (ORCID: https://orcid.org/0000-0003-3560-9433)
- Anthony C. Nichols (ORCID: https://orcid.org/0000-0002-0760-980X)
- Kevin Fung
- Shengjie Ying
- Halema Khan (ORCID: https://orcid.org/0000-0001-7343-5935)
- Matthew J. Cecchini (ORCID: https://orcid.org/0000-0001-7224-5216)
- Richard Inculet (ORCID: https://orcid.org/0000-0002-5437-7378)
- MohdWessam Al Jawhri (ORCID: https://orcid.org/0009-0006-5721-3383)
- Nhi Le
- Vanessa Dumeaux (ORCID: https://orcid.org/0000-0002-1280-6541)
- John W. Barrett (ORCID: https://orcid.org/0000-0002-4048-1692)
- Joe S. Mymryk (ORCID: https://orcid.org/0000-0002-3521-8005)
- Jennifer Anderson (ORCID: https://orcid.org/0000-0001-7080-9567)
- Elizabeth S. Woo
- R. Jun Lin (ORCID: https://orcid.org/0000-0003-1064-5868)
- Patrick MacInnis
- Krista Joris
Institutions
- Western University (CA)
- St. Michael's Hospital (CA)
- University of Toronto (CA)
Publication Details
- Journal
- The Laryngoscope
- Published
- 2025-05-06
- DOI
- https://doi.org/10.1002/lary.32214
- Primary Topic
- Tracheal and airway disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Academic Medical Organization of Southwestern Ontario
- American Laryngological Voice Research and Education Foundation