Optimizing mesenchymal stem cell therapy: from isolation to GMP-compliant expansion for clinical application
The study underscores the feasibility of FPMSCs for clinical uses under GMP conditions and emphasizes the importance of optimized culture protocols to improve cell proliferation and potency in MSC-based therapies.
Authors
- Daniel J. Kota
- Francesca Taraballi (ORCID: https://orcid.org/0000-0002-4959-1169)
- Patrick C. McCulloch (ORCID: https://orcid.org/0000-0002-9274-284X)
- Federica Banche Niclot
- Ricardo Bentes Azevedo (ORCID: https://orcid.org/0000-0002-2137-9588)
- Janaina Machado
- Sara Grace Rota
- Michael E. Williams (ORCID: https://orcid.org/0000-0001-5981-9983)
- Jaesang Lim
- Katia Castillo
- Samuel Adebiyi
- Ranga Sreenivasan
Institutions
- Houston Methodist (US)
- Methodist Hospital (US)
Publication Details
- Journal
- BMC Molecular and Cell Biology
- Published
- 2025-05-06
- DOI
- https://doi.org/10.1186/s12860-025-00539-7
- Citations
- 8
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 13.00
Funders
- Houston Methodist Hospital
- Houston Methodist Research Institute