Scaling HIV/AIDS Prevention and Treatment in Vulnerable Populations: Lessons from Global Health Interventions

Aim: This review aims to assess strategies for scaling up HIV/AIDS prevention and treatment in vulnerable populations, drawing on lessons from effective global health interventions. Study Design: This research systematically reviews studies on the scalability of HIV/AIDS interventions between 2019 and 2024 that concentrated on vulnerable populations. Methodology: Review of peer-reviewed articles from Google Scholar, PubMed, Scopus, and the Cochrane Library selected for relevance in regard to scaling interventions, with a particular emphasis on HIV/AIDS prevention and treatment among vulnerable populations. Studies were screened for publication date (2019–2024), focus on vulnerable groups, and emphasis on scalability of interventions. Non-English and non-peer-reviewed studies excluded. Results: Fifteen studies met the predetermined inclusion criteria. Findings highlight that scalable interventions will often depend on factors such as community engagement, cultural relevance, technology integration, and healthcare accessibility. It was very clear that the incorporation of these facets enhances intervention uptake among vulnerable populations. Conclusions: Effective scalability of HIV/AIDS interventions requires context-specific solutions driven by community inputs and sustainable resource allocations. Future research on scalable models should focus on long-term outcomes, emphasizing cost-effectiveness and adaptability to diverse socio-economic conditions.