Potential Roles of Serum Exosomal CD155 and its Impact on NK Cell Immunosuppression in Hepatocellular Carcinoma
These results disclose exo-CD155 shows promise for serving as a biomarker for HCC, especially in early-stage patients or those with normal AFP/AFP-L3 levels. Moreover, serum exosomes from HCC patients suppress NK cell immune functions through the TIGIT/CD155 pathway, contributing to immune tolerance in HCC.
Authors
- Wenjie Zhou (ORCID: https://orcid.org/0009-0004-8768-726X)
- Qingzhen Han (ORCID: https://orcid.org/0000-0001-7373-891X)
- Wenwen Chen
- Qing Chen
- Xiaoxin Wu (ORCID: https://orcid.org/0000-0001-9785-8916)
- Dongdong Sun (ORCID: https://orcid.org/0000-0002-5182-4398)
- Min-tuo Wang
- Jinrong Lv
- Fei Guo (ORCID: https://orcid.org/0009-0004-2149-7228)
- Wenzheng Han
- Gang Feng (ORCID: https://orcid.org/0000-0002-8378-8248)
- Xiaopeng Chen (ORCID: https://orcid.org/0000-0002-3087-5735)
- Min Li (ORCID: https://orcid.org/0000-0003-4682-7612)
- Yuxuan Yang (ORCID: https://orcid.org/0009-0000-5292-713X)
- Jia Bao
- Yingying Wang
Institutions
- Second Military Medical University (CN)
- Soochow University (CN)
- Changhai Hospital (CN)
- Second Affiliated Hospital of Soochow University (CN)
- First Affiliated Hospital Zhejiang University (CN)
- First Affiliated Hospital of Wannan Medical College (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Balkan Medical Journal
- Published
- 2025-05-06
- DOI
- https://doi.org/10.4274/balkanmedj.galenos.2025.2025-1-129
- Citations
- 4
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 3.19
Funders
- Fudan University