A Rare Case of Autoimmune Hemolytic Anemia and Suspected Acute Hemorrhagic Disseminated Encephalomyelitis Following Recent Vaccination

Autoimmune hemolytic anemia (AIHA) and acute disseminated encephalomyelitis (ADEM) are rare autoimmune complications that may follow infections or vaccinations. We present a case of a 77-year-old male patient who developed warm AIHA and rapid neurological decline suggestive of hemorrhagic ADEM following recent varicella and influenza vaccinations. Laboratory findings confirmed AIHA, and MRI revealed multifocal white matter lesions with hemorrhagic foci. Despite high-dose corticosteroid treatment, the patient's condition worsened, and he ultimately passed away.

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Publication Details

Journal
Cureus
Published
2025-05-06
DOI
https://doi.org/10.7759/cureus.83556
Primary Topic
Blood groups and transfusion
Type
article
Field-Weighted Citation Impact
0.00
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article

A Rare Case of Autoimmune Hemolytic Anemia and Suspected Acute Hemorrhagic Disseminated Encephalomyelitis Following Recent Vaccination

Kelly Samara da Silva, Hettiyadura Apsara Surangani Mendis Karunaratne
Cureus
Blood groups and transfusion
article

A Rare Case of Autoimmune Hemolytic Anemia and Suspected Acute Hemorrhagic Disseminated Encephalomyelitis Following Recent Vaccination

Kelly Samara da Silva, Hettiyadura Apsara Surangani Mendis Karunaratne
article en

Abstract

Autoimmune hemolytic anemia (AIHA) and acute disseminated encephalomyelitis (ADEM) are rare autoimmune complications that may follow infections or vaccinations. We present a case of a 77-year-old male patient who developed warm AIHA and rapid neurological decline suggestive of hemorrhagic ADEM following recent varicella and influenza vaccinations. Laboratory findings confirmed AIHA, and MRI revealed multifocal white matter lesions with hemorrhagic foci. Despite high-dose corticosteroid treatment, the patient's condition worsened, and he ultimately passed away.

CureusVol. 17(5)
North West Regional Hospital (AU)
Good health and well-being
Openalex Percentile: Top 88%
Blood groups and transfusion
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