Data integration methods for micro-randomized trials

Existing statistical methods for the analysis of micro-randomized trials (MRTs) are designed to estimate causal excursion effects using data from a single MRT. In practice, however, researchers can often find previous MRTs that employ similar interventions. In this paper, we develop data integration methods that capitalize on this additional information, leading to statistical efficiency gains. To further increase efficiency, we demonstrate how to combine these approaches according to a generalization of multivariate precision weighting that allows for correlation between estimates, and we show that the resulting meta-estimator possesses an asymptotic optimality property. We illustrate our methods in simulation and in a case study involving 2 MRTs in the area of smoking cessation, finding that the proposed methods can reduce standard errors by over 30% without sacrificing asymptotic unbiasedness or calibrated statistical inference.

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Publication Details

Journal
Biometrics
Published
2025-04-02
DOI
https://doi.org/10.1093/biomtc/ujaf002
Primary Topic
Advanced Causal Inference Techniques
Type
article
Field-Weighted Citation Impact
0.00

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article

Data integration methods for micro-randomized trials

Catherine G. Lam, Inbal Billie Nahum-Shani, David W. Wetter, Lindsey N. Potter et al.
Biometrics
Advanced Causal Inference Techniques
article

Data integration methods for micro-randomized trials

Catherine G. Lam, Inbal Billie Nahum-Shani, David W. Wetter, Lindsey N. Potter, Easton Huch, Walter Dempsey
article en

Abstract

Existing statistical methods for the analysis of micro-randomized trials (MRTs) are designed to estimate causal excursion effects using data from a single MRT. In practice, however, researchers can often find previous MRTs that employ similar interventions. In this paper, we develop data integration methods that capitalize on this additional information, leading to statistical efficiency gains. To further increase efficiency, we demonstrate how to combine these approaches according to a generalization of multivariate precision weighting that allows for correlation between estimates, and we show that the resulting meta-estimator possesses an asymptotic optimality property. We illustrate our methods in simulation and in a case study involving 2 MRTs in the area of smoking cessation, finding that the proposed methods can reduce standard errors by over 30% without sacrificing asymptotic unbiasedness or calibrated statistical inference.

BiometricsVol. 81(2)
University of Utah (US), University of Michigan (US), Huntsman Cancer Institute (US)
Huntsman Cancer Foundation
Good health and well-being
Openalex Percentile: Top 90%
Advanced Causal Inference Techniques
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Data integration methods for micro-randomized trials — Catherine G. Lam, Inbal Billie Nahum-Shani, et al. · Biometrics (2025) | TGRS Research Map | TGRS