Synthesis and evaluation of the anti-microbial activity of some Schiff bases of 1H-Indazole

The objective of this work was to perform the preparation of indazole nucleus and condense it with various aldehydes to obtain Schiff's bases and evaluate the in vitro antimicrobial action of these compounds against bacteria. The preparation of the target compounds (SBa-j) was done by condensation of 2,4-dichloro benzonitrile with hydrazines to yield 1H-imidazolyl followed by the imine linkage formation by interaction with the active carbonyl group of the aromatic aldehyde. The compounds were checked for solubility, melting point, and yield while the structural confirmation was done by IR and 1H-NMR. The antibacterial action of the prepared imidazolyl Schiff bases was tested against E. coli, P. aeruginosa, B. subtilis, and S. aureus. The zone of inhibition obtained from the disc diffusion method was used as the indication of antibacterial action.