The role of immune cell phenotypes and metabolites in the risk of ischemic stroke: a Mendelian randomization-based mediation analysis
Our study highlights the crucial roles of specific immune cell phenotypes and metabolites in IS, suggesting their potential as novel therapeutic targets or biomarkers. The mediation analysis underscores the complex interactions between immune cells and metabolites in IS, providing valuable insights for future research. These findings pave the way for further exploration of the pathophysiological mechanisms and therapeutic strategies for IS.
Authors
- Jiayun Zhang (ORCID: https://orcid.org/0000-0003-4369-2126)
- Tian-Tian Xu (ORCID: https://orcid.org/0000-0002-9127-7659)
- Zhe Zhang (ORCID: https://orcid.org/0000-0002-9303-8221)
- Rui Shi (ORCID: https://orcid.org/0000-0002-9374-0897)
- Yiting Gu
- Jinzhou Tian (ORCID: https://orcid.org/0009-0001-9867-7006)
- Shiduo Wang
- Qiming Liu (ORCID: https://orcid.org/0000-0002-5826-2164)
Institutions
- Hebei University of Chinese Medicine (CN)
- First Affiliated Hospital of Hebei Medical University (CN)
Publication Details
- Journal
- BMC Neurology
- Published
- 2025-05-06
- DOI
- https://doi.org/10.1186/s12883-025-04205-5
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00