Paridis Rhizoma Saponins ameliorate CCl4-induced liver fibrosis via modulation of the Nrf2-HO-1/NQO-1 and TGF-β1/Smads signaling pathways
These findings indicate that PRS can mitigate the impact of CCl<sub>4</sub>-induced liver fibrosis in experimental animals by upregulating the Nrf2-HO-1/NQO-1 and downregulating the TGF-β1/Smads signaling pathways.
Authors
- Hui Ao (ORCID: https://orcid.org/0000-0001-5763-6147)
- Xiaojun Yang (ORCID: https://orcid.org/0000-0002-0007-3715)
- Mingqiang Fu (ORCID: https://orcid.org/0000-0002-0957-1446)
- Yanquan Han (ORCID: https://orcid.org/0000-0001-7655-397X)
- Gang Cao (ORCID: https://orcid.org/0000-0002-0819-0430)
- Yan Hong
- Shuang Geng (ORCID: https://orcid.org/0000-0002-7566-6398)
Institutions
- Zhejiang Chinese Medical University (CN)
- Anhui University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Biochemistry and Biophysics Reports
- Published
- 2025-05-05
- DOI
- https://doi.org/10.1016/j.bbrep.2025.102040
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00