Effect of Hypoxia on the Biological Characteristics of MSCs

Mesenchymal stem cells(MSCs) possess biological characteristics such as self-replication and multipotential differentiation,playing a significant role in the treatment of various diseases. In traditional in vitro cell culture, the oxygen concentration is maintained at 20%, whereas in vivo and under many pathological conditions, cells reside in a hypoxia enviroment. By reviewing relevant literature on MSCs, this article addresses current challenges in stem cell transplantation technology. It explores the effects and mechanisms of hypoxia conditions on various biological characteristics of MSCs, including proliferation ability,migration ability,apoptosis and differentiation potential. The aim is to investigate whether hypoxia conditions can optimize the efficacy of MSCs, thereby identifying more suitable in vitro culture conditions to improve cell quality and enhance their application in clinical therapies.