Severe Aplastic Anemia Complicated with Fatal Invasive Fungal Infections in a Young Patient Harboring Perforin Gene Polymorphisms
The complex interplay between managing SAA and addressing invasive fungal infections, which remain a leading cause of mortality in immunocompromised patients, is highlighted in this case. The latter emphasizes the importance of prompt diagnosis and targeted treatment to alleviate infection-related complications while maintaining care continuity for the hematologic disorder. The detection of <i>PRF1</i> polymorphisms raises questions about their implication in immune regulation and disease trajectory, emphasizing the need for further research in this field.
Authors
- Christos Masaoutis (ORCID: https://orcid.org/0000-0003-0029-7046)
- Charalampos Pontikoglou (ORCID: https://orcid.org/0009-0002-7198-3887)
- Ioannis Liapis (ORCID: https://orcid.org/0000-0001-6240-4228)
- Elena E. Solomou (ORCID: https://orcid.org/0000-0002-8846-9422)
- Helen Α. Papadaki (ORCID: https://orcid.org/0000-0002-5146-9699)
- Nektaria Xirouchaki (ORCID: https://orcid.org/0000-0002-4101-1799)
- Ioanna Papakitsou
- Ioannis Kokkinakis (ORCID: https://orcid.org/0000-0002-0033-0988)
- Styliani Markatzinou
- Maria I. Krithinaki
Institutions
- University of Crete (GR)
- University of Patras (GR)
- University Hospital of Heraklion (GR)
- Evangelismos Hospital (GR)
Publication Details
- Journal
- Hematology Reports
- Published
- 2025-05-06
- DOI
- https://doi.org/10.3390/hematolrep17030025
- Citations
- 1
- Primary Topic
- Hematopoietic Stem Cell Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 1.77