The Renal Protective Function of Chrysin in Cisplatin-induced Kidney Toxicity: Insights From Bee-derived Natural Compounds

Chrysin in Cisplatininduced Kidney Toxicity: Insights From Bee-derived Natural Compounds Background: One common medication used in chemotherapy is cisplatin.Despite its effectiveness, it has side effects such as cytotoxicity and genotoxicity.Chrysin, a type of flavonoid, protects cells from free radicals and neutralizes them.Objectives: Our research focuses on the defensive effect of chrysin in counteracting the cytotoxic effects of cisplatin on Vero cells, which are a standard model. Methods:Cisplatin was placed in contact with the Vero cells at IC 50 concentration of cisplatin and a single dose of chrysin at 200 g/mL.The cells were pretreated with varying concentrations of chrysin (40, 80, 120, 160, and 200 g/mL).The study assessed cell viability, reactive oxygen species production, and glutathione levels. Results:The results of this research were an increase in cell viability, a decrease in the amount of reactive oxygen species, and an increase in the level of cellular glutathione in the groups treated with a higher concentration of chrysin. Conclusion:We found that chrysin can indeed protect cells from the damage caused by cisplatin, thanks to its antioxidant properties.We can use chrysin in our daily diet and also in combination with chemotherapy.