Evaluation of Anti-psoriatic Activity of Aloe sinkatana Extract on Imiquimod Induced Psoriatic-like Dermatitis in Mice

Evaluation of Anti-psoriatic Activity of Aloe sinkatana Extract on Imiquimod Induced Psoriatic-like Dermatitis in Mice Background: One of the most significant Sudanese medicinal plants is Aloe sinkatana, which has considerable pharmacological activity and has been historically used to treat psoriasis and other skin conditions.Objectives: This study aims to evaluate the A. sinkatana plant's anti-psoriatic properties. Methods:The imiquimod (IMQ)-induced psoriasis mice model was used to evaluate the anti-psoriatic effect of the A. sinkatana plant.So, the effects of 0.1% and 0.2% extracts of A. sinkatana extract on five groups of mice were assessed and compared with the conventional medication, i.e. dexamethasone.Differences between treatment groups were evaluated by a one-way analysis of variance, followed by a post hoc Fisher least significant difference test using the SPSS software, version 20.At P<0.05, differences were deemed significant.A minimum of three replicates were used in each duplicate experiment.For all values, MeanSD was used. Results:The extracts showed a significant and remarkably strong anti-psoriatic effect since the percentages of psoriasis-like symptoms were reduced in groups treated with 0.2% Aloe extract (A.E), 0.1% A.E, and dexamethasone 86%, 84%, and 68%, respectively.Both extract concentrations improved the psoriatic lesions and decreased the grading of the treated groups' psoriasis area and severity index (PASI) scale. Conclusion:Due to the constant research to develop a safe and effective topical preparation for the treatment of psoriasis, the current study provided an enhanced anti-psoriatic treatment, represented by A. sinkatana extract.This herb may be beneficial in the pharmaceutical formulation of new safe and effective medication for treating psoriasis.