FLASH-induced DNA damage reduction measured <i>in vitro</i> correlates with effective oxygen depletion determined <i>in silico</i>: further support for oxygen depletion contributing to FLASH’s reduced damage burden <i>in vitro</i>
Findings support TOD as a key mechanism for the reduced damage burden of FLASH in vitro. However, further work is required to demarcate the sparing effects of FLASH in vivo.
Authors
- George D.D. Jones (ORCID: https://orcid.org/0000-0002-9543-2206)
- Jan Schuemann (ORCID: https://orcid.org/0000-0002-7554-8818)
- Bethany Rothwell (ORCID: https://orcid.org/0000-0002-3323-671X)
- K.J. Kirkby (ORCID: https://orcid.org/0000-0002-0901-210X)
- Michael J. Merchant (ORCID: https://orcid.org/0000-0001-8422-5255)
- Donald J. L. Jones (ORCID: https://orcid.org/0000-0001-6583-870X)
- N.F. Kirkby (ORCID: https://orcid.org/0000-0001-5352-8069)
- Kristoffer Petersson (ORCID: https://orcid.org/0000-0003-0300-5790)
- C. Cooper (ORCID: https://orcid.org/0000-0003-3802-8837)
Institutions
- Harvard University (US)
- University of Leicester (GB)
- University of Manchester (GB)
- University of Oxford (GB)
- Massachusetts General Hospital (US)
- CRUK/MRC Oxford Institute for Radiation Oncology (GB)
- Skåne University Hospital (SE)
Publication Details
- Journal
- British Journal of Radiology
- Published
- 2025-05-06
- DOI
- https://doi.org/10.1093/bjr/tqaf097
- Citations
- 3
- Primary Topic
- Radiation Therapy and Dosimetry
- Type
- article
- Field-Weighted Citation Impact
- 4.56
Funders
- U.S. Department of Health and Human Services
- Cancer Research UK
- University of Leicester
- National Institutes of Health
- Medical Research Council
- National Cancer Institute