Sex- and age-related differences in LPS-induced lung injury: establishing a mouse intensive care unit
We successfully established a mouse intensive care unit that integrated all critical aspects of a human intensive care unit simultaneously. By highlighting sex- and age-related differences following lipopolysaccharide stimulation and mechanical ventilation, our study underscored the need for diversity in preclinical models to improve translation of findings on critical illnesses like acute lung injury into clinical settings.
Authors
- Kai Zacharowski (ORCID: https://orcid.org/0000-0002-0212-9110)
- Ulrike Heinicke
- Sandra Weber
- Andrea Hoffmann (ORCID: https://orcid.org/0000-0003-2318-8985)
- Steven Roger Talbot (ORCID: https://orcid.org/0000-0002-9062-4065)
- Annett Wilken‐Schmitz
- Lucy Kathleen Reiss (ORCID: https://orcid.org/0000-0001-9567-3328)
- Andreas von Knethen (ORCID: https://orcid.org/0000-0002-5831-0365)
- Michael Gröger
- Ch. G. Crispens
- Kernt Köhler
- Laurel Kastner (ORCID: https://orcid.org/0000-0002-3562-6690)
- Peter Radermacher
- Emilia Fleckenstein
Institutions
- Goethe University Frankfurt (DE)
- Justus-Liebig-Universität Gießen (DE)
- Medizinische Hochschule Hannover (DE)
- Helmholtz-Institute Ulm (DE)
- University Hospital Frankfurt (DE)
- RWTH Aachen University (DE)
Publication Details
- Journal
- Intensive Care Medicine Experimental
- Published
- 2025-05-06
- DOI
- https://doi.org/10.1186/s40635-025-00756-6
- Citations
- 4
- Primary Topic
- Respiratory Support and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 6.07