Depression of intracranial self-stimulation in male and female rats by intraperitoneal lactic acid: effects of morphine, ketoprofen, and interactions with G-protein biased kappa opioid agonists
These data suggest that these G-protein biased kappa agonists may lack sufficient efficacy or potency to alter the effects of opioids or NSAIDs against moderate to severe antinociceptive stimuli in rats, and development of more potent or efficacious compounds may be required to demonstrate efficacy in rat models of moderate to severe nociception.
Authors
- Laura Bohn (ORCID: https://orcid.org/0000-0002-6474-8179)
- Sara R. Jones (ORCID: https://orcid.org/0000-0002-3424-7576)
- Thomas J. Martin (ORCID: https://orcid.org/0000-0003-2800-5308)
- Bruce E. Blough (ORCID: https://orcid.org/0000-0003-3515-0896)
- C. Martin (ORCID: https://orcid.org/0000-0003-2480-2916)
- Kevin J. Frankowski (ORCID: https://orcid.org/0000-0002-7173-6352)
- Jeffrey Aubé (ORCID: https://orcid.org/0000-0003-1049-5767)
Institutions
- University of North Carolina at Chapel Hill (US)
- Scripps Research Institute (US)
- RTI International (US)
- Wake Forest University (US)
Publication Details
- Journal
- Psychopharmacology
- Published
- 2025-05-06
- DOI
- https://doi.org/10.1007/s00213-025-06800-3
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wake Forest University
- National Institutes of Health
- National Institute on Drug Abuse