D-Dimer/Fibrinogen Ratio as a Prominent Predictor of Mortality in COVID-19 Patients Admitted To the Intensive Care Unit

Purpose: In this retrospective cohort study, evaluating the role of the D-dimer/fibrinogen ratio in predicting the in-hospital mortality rate of COVID-19 regardless of the presence of comorbidities was aimed. Materials and Methods: This retrospective cohort study included patients admitted to the intensive care unit. The demographic data of the patients (sex, age, body mass index, comorbidities), their prognostic clinical scores, laboratory results, and need for and duration of invasive mechanical ventilation (IMV) were recorded. Results: The rates of chronic renal diseases, acute renal failure, cardiac diseases, and severe sepsis were significantly higher in the exitus group. It was found that lower levels of lymphocytes were associated with increased mortality. Furthermore, neutrophil counts and the neutrophil to lymphocyte ratio (NLR) were associated with increased mortality. A higher D-dimer/fibrinogen ratio (DDFR) was a predictor of mortality but not a predictor of the duration of hospitalization in the ICU. Conclusion: DDFR has a potential impact in anticipating mortality rates in COVID-19 patients.