Insertion sequences accelerate genomic convergence of multidrug resistance and hypervirulence in Klebsiella pneumoniae via capsular phase variation
Our findings reveal that IS elements mediate capsular phase variation by toggling gene activity, accelerating the genomic convergence of multidrug resistance and hypervirulence in K. pneumoniae, as well as facilitating adaptive transitions in different environments.
Authors
- Qi Chen (ORCID: https://orcid.org/0009-0001-2316-4521)
- Yuqin Song (ORCID: https://orcid.org/0000-0001-5451-6481)
- Xiaofei Tian (ORCID: https://orcid.org/0000-0001-8642-2033)
- Jie Feng (ORCID: https://orcid.org/0000-0001-5172-6643)
- Gang Zhang (ORCID: https://orcid.org/0000-0003-0774-5710)
- Dawei Wei (ORCID: https://orcid.org/0000-0002-2250-1354)
- Chao Wang (ORCID: https://orcid.org/0000-0002-4136-0112)
- Yi Li (ORCID: https://orcid.org/0000-0002-5849-6040)
- Jiangqing Huang
- Linhuan Wu (ORCID: https://orcid.org/0000-0002-5255-1846)
Institutions
- Institute of Mechanics (CN)
- Shandong First Medical University (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Genome Medicine
- Published
- 2025-05-06
- DOI
- https://doi.org/10.1186/s13073-025-01474-0
- Citations
- 13
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 7.69
Funders
- Chinese Academy of Sciences
- National Key Research and Development Program of China