Surveying local CAR T-cell manufacturing processes to facilitate standardization and expand accessibility

This study highlights the widespread adoption of local CAR T-cell manufacturing and the significant variability in production processes across institutions. The findings emphasize the importance of establishing quality control benchmarks and data reporting frameworks to improve product consistency and access to CAR T-cell therapies. Addressing barriers such as cost, infrastructure, and regulatory challenges through standardization efforts and international collaboration could enhance the reproducibility, scalability, and accessibility of CAR T-cell therapies globally.

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Publication Details

Journal
Journal of Translational Medicine
Published
2025-05-06
DOI
https://doi.org/10.1186/s12967-025-06400-x
Citations
13
Primary Topic
CAR-T cell therapy research
Type
article
Field-Weighted Citation Impact
13.59
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article

Surveying local CAR T-cell manufacturing processes to facilitate standardization and expand accessibility

Beth H. Shaz, Deven K. Gupta
13 citations
Journal of Translational Medicine
CAR-T cell therapy research
13.59
article

Surveying local CAR T-cell manufacturing processes to facilitate standardization and expand accessibility

Beth H. Shaz, Deven K. Gupta
article en
13 citations

Abstract

This study highlights the widespread adoption of local CAR T-cell manufacturing and the significant variability in production processes across institutions. The findings emphasize the importance of establishing quality control benchmarks and data reporting frameworks to improve product consistency and access to CAR T-cell therapies. Addressing barriers such as cost, infrastructure, and regulatory challenges through standardization efforts and international collaboration could enhance the reproducibility, scalability, and accessibility of CAR T-cell therapies globally.

Journal of Translational MedicineVol. 23(1)
Duke University (US), Duke Institute for Health Innovation (US), Marcus (United States) (US)
Industry, innovation and infrastructure
Openalex Percentile: Top 1%
CAR-T cell therapy research
13.59
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Surveying local CAR T-cell manufacturing processes to facilitate standardization and expand accessibility — Beth H. Shaz, Deven K. Gupta · Journal of Translational Medicine (2025) | TGRS Research Map | TGRS