8MW0511, a novel, long-acting granulocyte-colony stimulating factor fusion protein for the prevention of chemotherapy-induced neutropenia: final results from the phase III clinical trial
The study findings confirm that 8MW0511 is not inferior to PEG-rhG-CSF in terms of efficacy and shows comparable safety profiles. Additionally, 8MW0511 has the potential to significantly decrease the duration of chemotherapy-induced neutropenia, along with a reduction in the occurrence of FN and severe neutropenia.
Authors
- Xiuchun Chen (ORCID: https://orcid.org/0000-0002-7134-7170)
- Ruizhen Luo
- Jingfen Wang
- Baojiang Li (ORCID: https://orcid.org/0000-0002-7952-6691)
- Zhiye Zhang (ORCID: https://orcid.org/0000-0002-1661-2277)
- Yu Ren (ORCID: https://orcid.org/0000-0003-2928-138X)
- Xujuan Wang
- Jun Jia (ORCID: https://orcid.org/0000-0001-7585-755X)
- Biyun Wang
- Xinjian Jia (ORCID: https://orcid.org/0000-0003-0708-692X)
- Xichun Hu (ORCID: https://orcid.org/0000-0001-6148-9186)
- Xuchen Cao (ORCID: https://orcid.org/0000-0003-3216-6673)
- Yi Tu (ORCID: https://orcid.org/0000-0003-1709-2688)
- Honghuan Zhao
- Jiazhuan Mei (ORCID: https://orcid.org/0000-0002-1040-643X)
- Chaolong Zhu
- Zhihua Li (ORCID: https://orcid.org/0000-0003-2003-5457)
- Hongtao Li (ORCID: https://orcid.org/0000-0002-1290-0917)
- Cuizhi Geng (ORCID: https://orcid.org/0000-0001-5541-5412)
- Pei Wang (ORCID: https://orcid.org/0000-0002-6890-6453)
- Liuzhong Yang
- Lu Song
- Guosheng Ren (ORCID: https://orcid.org/0000-0002-6416-8967)
- Jian Chen (ORCID: https://orcid.org/0000-0003-1090-5586)
- Xiaojia Wang (ORCID: https://orcid.org/0000-0002-7005-0842)
- Jincheng Li (ORCID: https://orcid.org/0000-0003-4550-2808)
- Caixia Liu (ORCID: https://orcid.org/0000-0003-1760-8752)
- Yue-Yin Pan (ORCID: https://orcid.org/0000-0003-0254-7272)
- Yiding Chen (ORCID: https://orcid.org/0000-0002-2263-6275)
- Jing Sun (ORCID: https://orcid.org/0000-0002-5130-4835)
- Chao Deng (ORCID: https://orcid.org/0000-0003-1661-2450)
- Tao Sun (ORCID: https://orcid.org/0000-0002-6066-5915)
- Yunhui Huang
- Shuhai Wang (ORCID: https://orcid.org/0000-0003-2888-1922)
- Ming‐De Huang (ORCID: https://orcid.org/0000-0001-8907-0790)
- Shiyou Yu (ORCID: https://orcid.org/0009-0003-9811-9332)
- Jingming Dong
- Shao‐Qing Cai (ORCID: https://orcid.org/0009-0003-2711-4016)
- Yumin Yao
- Zhidong Pei
Institutions
- Qingdao University (CN)
- Hebei Medical University (CN)
- Shanghai Medical College of Fudan University (CN)
- Chongqing University (CN)
- Tianjin Medical University Cancer Institute and Hospital (CN)
- Yuhuangding Hospital (CN)
- Wuhan University (CN)
- Zhengzhou University (CN)
- Fudan University Shanghai Cancer Center (CN)
- Suizhou Central Hospital (CN)
- Huaian First People’s Hospital (CN)
- Zhejiang Cancer Hospital (CN)
- Cangzhou Central Hospital (CN)
- Fourth Hospital of Hebei Medical University (CN)
- People's Hospital of Cangzhou (CN)
- Deyang Stomatological Hospital (CN)
- First Affiliated Hospital of Xinxiang Medical University (CN)
- Suzhou Municipal Hospital (CN)
- Neijiang Normal University (CN)
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- Dongguan People’s Hospital (CN)
- Luoyang Central Hospital Affiliated to Zhengzhou University (CN)
- Chongqing Three Gorges Central Hospital (CN)
- Anhui Provincial Hospital (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- First Affiliated Hospital of Henan University of Science and Technology (CN)
- Renmin Hospital of Wuhan University (CN)
- Henan Cancer Hospital (CN)
- Xian Yang Central Hospital (CN)
- First Affiliated Hospital of Bengbu Medical College (CN)
- Taian City Central Hospital (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- Liaocheng People's Hospital (CN)
- Liaoning Cancer Hospital & Institute (CN)
- Anyang Tumor Hospital (CN)
- Inner Mongolia Medical University (CN)
- Nanjing Medical University (CN)
- Jinzhou Medical University (CN)
- Chongqing Medical University (CN)
- China Medical University (CN)
Publication Details
- Journal
- Breast Cancer Research
- Published
- 2025-05-06
- DOI
- https://doi.org/10.1186/s13058-025-02010-z
- Citations
- 1
- Primary Topic
- Neutropenia and Cancer Infections
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- Inner Mongolia Medical University
- Henan University of Chinese Medicine
- Chongqing University
- Henan University of Science and Technology
- Chongqing Medical University
- Henan University
- Zhejiang University
- Wuhan University
- Nanjing Medical University
- China Medical University
- University of Science and Technology of China
- Qingdao University
- Xinxiang Medical University
- Hebei Medical University
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
- Renmin Hospital of Wuhan University