Gut microbiota modulates lung gene expression and metabolism to aid SD rats in adapting to low-pressure hypoxia
We report the beneficial effects of FMT on respiratory capacity, lung metabolism, and lung gene expression in SD rats under hypoxic conditions. We revealed the inhibitory effects of gut microbiota on lung mast cells and histamine expression under hypoxic conditions. The study demonstrated the potential effectiveness of treating HPH through FMT and offers insights into improving hypoxia adaptation.
Authors
- Shatuo Chai
- Dongwen Dai (ORCID: https://orcid.org/0000-0003-2252-2662)
- Shuxiang Wang (ORCID: https://orcid.org/0000-0001-7649-8878)
- Kaiyue Pang
- Jianmei Wang (ORCID: https://orcid.org/0000-0003-2811-4344)
- Yuxia Ding (ORCID: https://orcid.org/0000-0002-0128-1970)
- Tanqin Dong
- Zheng Chen (ORCID: https://orcid.org/0000-0002-4940-2225)
- Shujie Liu
Institutions
- Qinghai University (CN)
- Animal Husbandry & Veterinary (IN)
- China Agricultural University (CN)
Publication Details
- Journal
- Microbiology Spectrum
- Published
- 2025-05-06
- DOI
- https://doi.org/10.1128/spectrum.00045-25
- Citations
- 6
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 4.84