Multi-omics analysis reveals immunosuppression in oesophageal squamous cell carcinoma induced by creatine accumulation and HK3 deficiency
Our analysis reveals molecular variation in multi-omics linkages and identifies targets that reverse the immunosuppressive microenvironment through metabolic remodelling improving immunotherapy and targeted therapy for ESCC.
Authors
- Ruifang Sun (ORCID: https://orcid.org/0000-0002-4791-3734)
- Xiaoyan Meng
- Yikun Cheng
- Wei-Min Zhang (ORCID: https://orcid.org/0000-0003-2117-3608)
- Yingzhen Gao
- Binbin Zou (ORCID: https://orcid.org/0000-0002-9467-8802)
- Xinyuan Shen (ORCID: https://orcid.org/0009-0005-9057-4589)
- Bin Yang
- Kun Zheng (ORCID: https://orcid.org/0000-0001-5814-1904)
- Xuefei Feng
- Ling Zhang (ORCID: https://orcid.org/0000-0002-4100-0475)
- Heyang Cui (ORCID: https://orcid.org/0000-0002-8061-6096)
- Lunzhi Dai (ORCID: https://orcid.org/0000-0002-3003-8910)
- Yuanfang Zhai
- Yongping Cui (ORCID: https://orcid.org/0000-0002-5961-4125)
- Fang Wang (ORCID: https://orcid.org/0000-0003-0139-7209)
- Hongyi Li (ORCID: https://orcid.org/0000-0001-5507-0039)
- Xiaolong Cheng (ORCID: https://orcid.org/0000-0003-4332-8527)
- Yanqiang Wang (ORCID: https://orcid.org/0000-0002-7552-3792)
- Ning Ding (ORCID: https://orcid.org/0000-0001-5726-1840)
- Yanlin Guo (ORCID: https://orcid.org/0000-0003-0636-9223)
- Siyu He (ORCID: https://orcid.org/0000-0001-7187-3034)
- Yongsheng Meng (ORCID: https://orcid.org/0000-0001-8063-7682)
- Enwei Xu
- Pengzhou Kong
Institutions
- Shanxi Medical University (CN)
- Chinese University of Hong Kong (HK)
- Sichuan University (CN)
- Shanxi Provincial Cancer Hospital (CN)
- Peking University Shenzhen Hospital (CN)
- University of Hong Kong - Shenzhen Hospital (CN)
- Shanxi Academy of Medical Sciences (CN)
Publication Details
- Journal
- Genome Medicine
- Published
- 2025-05-06
- DOI
- https://doi.org/10.1186/s13073-025-01465-1
- Citations
- 5
- Primary Topic
- Biochemical and Molecular Research
- Type
- article
- Field-Weighted Citation Impact
- 4.03
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China