Multi-omics analysis reveals immunosuppression in oesophageal squamous cell carcinoma induced by creatine accumulation and HK3 deficiency

Our analysis reveals molecular variation in multi-omics linkages and identifies targets that reverse the immunosuppressive microenvironment through metabolic remodelling improving immunotherapy and targeted therapy for ESCC.

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Publication Details

Journal
Genome Medicine
Published
2025-05-06
DOI
https://doi.org/10.1186/s13073-025-01465-1
Citations
5
Primary Topic
Biochemical and Molecular Research
Type
article
Field-Weighted Citation Impact
4.03

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article

Multi-omics analysis reveals immunosuppression in oesophageal squamous cell carcinoma induced by creatine accumulation and HK3 deficiency

Ruifang Sun, Xiaoyan Meng, Yikun Cheng, Wei-Min Zhang et al.
5 citations
Genome Medicine
Biochemical and Molecular Research
4.03
article

Multi-omics analysis reveals immunosuppression in oesophageal squamous cell carcinoma induced by creatine accumulation and HK3 deficiency

Ruifang Sun, Xiaoyan Meng, Yikun Cheng, Wei-Min Zhang, Yingzhen Gao, Binbin Zou, Xinyuan Shen, Bin Yang, Kun Zheng, Xuefei Feng, Ling Zhang, Heyang Cui, Lunzhi Dai, Yuanfang Zhai, Yongping Cui, Fang Wang, Hongyi Li, Xiaolong Cheng, Yanqiang Wang, Ning Ding, Yanlin Guo, Siyu He, Yongsheng Meng, Enwei Xu, Pengzhou Kong
article en
5 citations

Abstract

Our analysis reveals molecular variation in multi-omics linkages and identifies targets that reverse the immunosuppressive microenvironment through metabolic remodelling improving immunotherapy and targeted therapy for ESCC.

Genome MedicineVol. 17(1)
Shanxi Medical University (CN), Chinese University of Hong Kong (HK), Sichuan University (CN), Shanxi Provincial Cancer Hospital (CN), Peking University Shenzhen Hospital (CN), University of Hong Kong - Shenzhen Hospital (CN), Shanxi Academy of Medical Sciences (CN)
National Natural Science Foundation of China, National Key Research and Development Program of China
Zero hunger
Openalex Percentile: Top 6%
Biochemical and Molecular Research
4.03
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