AXL promotes inflammatory breast cancer progression by regulating immunosuppressive macrophage polarization
AXL signaling promotes IBC growth by inducing M2 macrophage polarization and driving the secretion of immunosuppressive molecules and cytokines via STAT6 signaling, thereby contributing to an immunosuppressive TME. Collectively, these findings highlight the potential of targeting AXL signaling as a novel therapeutic approach for IBC that warrants further investigation in clinical trials.
Authors
- Yating Cheng (ORCID: https://orcid.org/0000-0002-2352-8647)
- Fang Zou
- Savitri Krishnamurthy (ORCID: https://orcid.org/0000-0001-9030-4136)
- Jennifer M. Rosenbluth (ORCID: https://orcid.org/0000-0003-1314-6976)
- Lan Thi Phi (ORCID: https://orcid.org/0000-0003-3967-2747)
- Steven L. Warner (ORCID: https://orcid.org/0000-0002-6596-1676)
- Jason M. Foulks (ORCID: https://orcid.org/0000-0002-7883-2347)
- James P. Long (ORCID: https://orcid.org/0000-0001-5853-5938)
- Yohei Funakoshi (ORCID: https://orcid.org/0000-0001-7793-5013)
- Steven Van Laere (ORCID: https://orcid.org/0000-0002-2640-0040)
- Suguru Ogata (ORCID: https://orcid.org/0000-0002-5221-7362)
- Pascal Finetti (ORCID: https://orcid.org/0000-0002-2674-3123)
- Naoto Tada Ueno (ORCID: https://orcid.org/0000-0002-0166-7275)
- François Bertucci (ORCID: https://orcid.org/0000-0002-0157-0959)
- Debu Tripathy (ORCID: https://orcid.org/0000-0002-5711-2404)
- Anil K. Sood
- James M. Reuben
- Xiaoping Wang
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- University of Antwerp (BE)
- University of California, San Francisco (US)
- Sumitomo Dainippon Pharma (United States) (US)
- Institut Paoli-Calmettes (FR)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- Breast Cancer Research
- Published
- 2025-05-06
- DOI
- https://doi.org/10.1186/s13058-025-02015-8
- Citations
- 4
- Primary Topic
- Phagocytosis and Immune Regulation
- Type
- article
- Field-Weighted Citation Impact
- 3.19
Funders
- U.S. Department of Defense
- Breast Cancer Research Foundation
- National Institutes of Health
- University of Texas MD Anderson Cancer Center
- National Cancer Institute