Bone marrow mesenchymal stem cells transport connexin43 via tunneling nanotubes to alleviate isopreterenol-induced myocardial hypertrophy
Our results demonstrate that ISO promotes the formation of TNTs, particularly between MSCs and CMs, and induces changes in the morphology of TNTs (thickening and lengthening). Additionally, MSCs transmitted Cx43 to CMs via TNTs, which contributes to the alleviation of ISO-induced myocardial hypertrophy. These results suggest that TNTs represent an important mechanism in MSC-mediated therapy for myocardial hypertrophy.
Authors
- Zhong Xian
- Hongfeng Jiang (ORCID: https://orcid.org/0000-0002-1600-3236)
- Changrong Shao
- Jianghui Zhang
- Wenxiu Lu (ORCID: https://orcid.org/0009-0006-0237-2379)
- Sanbao Chai (ORCID: https://orcid.org/0000-0002-8746-518X)
- Yue Li (ORCID: https://orcid.org/0000-0002-1271-0283)
- Sa Liu (ORCID: https://orcid.org/0000-0002-8106-0392)
- Limin Zhao (ORCID: https://orcid.org/0000-0003-2851-6415)
Institutions
- Peking University (CN)
- Guangzhou Blood Center (CN)
- Beijing Anzhen Hospital (CN)
- Beijing Institute of Water (CN)
- Peking University International Hospital (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-05-06
- DOI
- https://doi.org/10.1186/s13287-025-04339-w
- Citations
- 2
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 2.78
Funders
- National Natural Science Foundation of China
- Tsinghua University
- Natural Science Foundation of Beijing Municipality
- Peking University