Lateral habenula-rostromedial tegmental nucleus circuit mediates inflammatory pain in mice
Our results indicate that activating glutamatergic neurons within the LHb heightens pain sensitivity by triggering GABAergic neurons in the RMTg, which in turn influences neuronal activity in the DRN. This research offers fresh perspectives on the pain mechanism, potentially revealing new therapeutic avenues for managing inflammatory pain.
Authors
- Shiheng An (ORCID: https://orcid.org/0000-0003-1313-2953)
- Jing Cao (ORCID: https://orcid.org/0000-0002-1690-8721)
- Danyang Zhao (ORCID: https://orcid.org/0000-0002-5548-3367)
- Zhiguo Shi (ORCID: https://orcid.org/0000-0001-9160-048X)
- Guoyan Zhao (ORCID: https://orcid.org/0000-0001-5615-6774)
- Yanfei Sun
- Guangjian Li
- Xuxin Wang
- Chunpeng Xu
- J. Xiao (ORCID: https://orcid.org/0000-0002-7860-3958)
- Xiaofeng Liu (ORCID: https://orcid.org/0000-0001-9800-6870)
- Chi Zhang (ORCID: https://orcid.org/0000-0002-6729-1426)
- Jiangtao Sun
- Hua Zhao (ORCID: https://orcid.org/0000-0002-5507-9647)
- Jing Yang (ORCID: https://orcid.org/0000-0001-7583-6185)
- Dongjie Sun (ORCID: https://orcid.org/0009-0005-2951-5213)
Institutions
- Union Hospital (HK)
- Jilin University (CN)
- Changchun Normal University (CN)
- Peer Intelligence Technology (China) (CN)
- First Hospital of Jilin University (CN)
Publication Details
- Journal
- The Journal of Headache and Pain
- Published
- 2025-05-06
- DOI
- https://doi.org/10.1186/s10194-025-02052-w
- Citations
- 2
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.33
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- People's Government of Jilin Province
- Changchun Normal University
- Directorate for Biological Sciences