Computational analysis of whole slide images predicts PD-L1 expression and progression-free survival in immunotherapy-treated non-small cell lung cancer patients
Our models, based on the analysis of histological images, can serve as predictive biomarkers for PD-L1 and PFS. This approach, focused on histological images, enables the distinction of patients based on treatment response, thus providing clinicians with a valuable tool for patient management. With further validation on external cohorts, these models could enhance clinical decision-making through analysis of routine medical images.
Authors
- Andréanne Gagné (ORCID: https://orcid.org/0000-0002-3833-4159)
- Michele Orain
- Mathieu Laplante (ORCID: https://orcid.org/0000-0002-1752-6741)
- Sevinj Yolchuyeva (ORCID: https://orcid.org/0000-0001-6760-1546)
- Bertrand Routy (ORCID: https://orcid.org/0000-0002-0756-6571)
- Marion Tonneau (ORCID: https://orcid.org/0000-0003-4776-115X)
- Wiam Belkaïd
- Arielle Elkrief (ORCID: https://orcid.org/0000-0003-1981-1535)
- Alona Kolnohuz
- Drew F. K. Williamson (ORCID: https://orcid.org/0000-0003-1745-8846)
- Venkata Manem (ORCID: https://orcid.org/0000-0003-1427-2819)
- Steve Bilodeau (ORCID: https://orcid.org/0000-0002-9799-3832)
- Fabien Lamaze
- Abdou Khadir Dia (ORCID: https://orcid.org/0000-0001-9820-7197)
- Philippe Joubert (ORCID: https://orcid.org/0000-0001-7784-6387)
- François Coulombe (ORCID: https://orcid.org/0000-0002-6273-227X)
- Florence Blais
- Julie Malo (ORCID: https://orcid.org/0009-0005-3613-2210)
Institutions
- Emory University (US)
- Lung Institute (US)
- Centre hospitalier de l'Université Laval (CA)
- Centre Hospitalier de l’Université de Montréal (CA)
- Université Laval (CA)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-05-06
- DOI
- https://doi.org/10.1186/s12967-025-06487-2
- Citations
- 4
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 4.18
Funders
- Institut de Valorisation des Données
- Fonds de Recherche du Québec - Santé