Mapping the natural history of amyotrophic lateral sclerosis: time-to-event analysis of clinical milestones in the pan-European, population-based PRECISION-ALS cohort
Our analysis of a large, well-defined, population-based European cohort provides detailed insight into the natural history of ALS, highlighting phenotypic and genetic factors affecting time to key clinical milestones. Further study is needed to determine the drivers in observed differences between ALS clinical center cohorts in time to clinical interventions and overall survival.
Authors
- Carlos Pastor‐Vargas (ORCID: https://orcid.org/0000-0002-4678-7967)
- Harry E. McDonough
- Miriam Galvin (ORCID: https://orcid.org/0000-0002-8232-8020)
- O. J. M. Holmdahl
- Orla M. Hardiman (ORCID: https://orcid.org/0000-0003-2610-1291)
- Fouke Ombelet (ORCID: https://orcid.org/0000-0003-1530-0869)
- Ammar Al‐Chalabi (ORCID: https://orcid.org/0000-0002-4924-7712)
- Nikita Lamaire
- Christopher J. McDermott (ORCID: https://orcid.org/0000-0002-1269-9053)
- Sarah Opie-Martin (ORCID: https://orcid.org/0000-0003-0951-8589)
- Ruben P. A. van Eijk (ORCID: https://orcid.org/0000-0002-7132-5967)
- Umberto Manera (ORCID: https://orcid.org/0000-0002-9995-8133)
- Caroline Ingre (ORCID: https://orcid.org/0000-0001-5327-7204)
- Rosario Vasta (ORCID: https://orcid.org/0000-0002-0393-4736)
- Leonard H. van den Berg (ORCID: https://orcid.org/0000-0002-5203-9674)
- Jan H. Veldink (ORCID: https://orcid.org/0000-0001-5572-9657)
- Michael A. van Es (ORCID: https://orcid.org/0000-0002-7709-5883)
- Stefan Sennfält (ORCID: https://orcid.org/0000-0002-7114-2757)
- Robert McFarlane (ORCID: https://orcid.org/0000-0001-7380-4219)
- Pamela J. Shaw (ORCID: https://orcid.org/0000-0002-8925-2567)
- Adriano Chiò (ORCID: https://orcid.org/0000-0001-9579-5341)
- Éanna Mac Domhnaill (ORCID: https://orcid.org/0009-0001-1197-9950)
- Daphne N. Weemering (ORCID: https://orcid.org/0009-0005-4182-3294)
- Frederik Hobin (ORCID: https://orcid.org/0009-0005-2167-5896)
- Mark Heverin
- Philippe Corcia
- Mónica Povedano Panadés
- Alejandro Caravaca Puchades
- Mohammed Mouzouri
Institutions
- Université de Tours (FR)
- Allen Institute for Brain Science (US)
- Karolinska University Hospital (SE)
- Inserm (FR)
- King's College London (GB)
- Trinity College Dublin (IE)
- Bellvitge University Hospital (ES)
- Botsford Hospital (US)
- Karolinska Institutet (SE)
- University Medical Center Utrecht (NL)
- Institut d'Investigació Biomédica de Bellvitge (ES)
- Centre Hospitalier Universitaire de Tours (FR)
- Laboratoire National de Référence (MA)
- Neuroscience Institute (IT)
- Beaumont Hospital, Dearborn (US)
- King's College Hospital (GB)
- University of Turin (IT)
- Oklahoma State University Center for Health Sciences (US)
- University of Sheffield (GB)
- KU Leuven (BE)
Publication Details
- Journal
- Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
- Published
- 2025-05-06
- DOI
- https://doi.org/10.1080/21678421.2024.2448535
- Citations
- 3
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 4.17