Diagnosis and treatment of iron deficiency in chronic heart failure
Iron deficiency (ID) is a common comorbidity in heart failure (HF), affecting 55% of chronic and up to 80% of acute HF patients, regardless of ejection fraction (EF). An ID is associated with reduced quality of life, impaired exercise capacity (VO<sub>2</sub> peak), higher hospitalization rate and lower survival rate. It is also an independent predictor of HF outcomes. This consensus statement critically reviews the diagnostic criteria for ID in HF and provides recommendations for their use. The efficacy and safety of intravenous iron supplements, including ferric carboxymaltose (FCM) and ferric derisomaltose (FDI), are analyzed highlighting the indications and potential adverse effects. Key clinical trials and guideline recommendations are summarized. In summary, the document addresses the diagnostics, treatment and monitoring of ID in HF.
Authors
- Anna Rab
- Rudolf Berger (ORCID: https://orcid.org/0000-0002-1712-0100)
- Peter P. Rainer (ORCID: https://orcid.org/0000-0002-2840-6454)
- Christopher Adlbrecht (ORCID: https://orcid.org/0000-0003-3743-3881)
- Martin Hülsmann (ORCID: https://orcid.org/0000-0001-7944-7363)
- Gerhard Pölzl (ORCID: https://orcid.org/0000-0002-2588-6739)
- Johann Altenberger (ORCID: https://orcid.org/0000-0002-5473-0418)
- Johann Auer (ORCID: https://orcid.org/0000-0001-6464-7661)
- Moritz Messner (ORCID: https://orcid.org/0000-0003-3250-4353)
- Christian Ebner (ORCID: https://orcid.org/0000-0003-2206-1907)
- Jakob Dörler (ORCID: https://orcid.org/0000-0003-0897-7281)
- Deddo Mörtl
- Marc‐Michael Zaruba (ORCID: https://orcid.org/0000-0003-1074-5463)
- Robert Berent
- Thomas Weber (ORCID: https://orcid.org/0000-0003-0617-0417)
- Friedrich Fruhwald
Institutions
- Innsbruck Medical University (AT)
- Medical University of Graz (AT)
- Music and Arts University of the City of Vienna (AT)
- Klinikum Klagenfurt (AT)
- University of Applied Sciences Burgenland (AT)
- St. Josefs Hospital (DE)
- BioTechMed-Graz (AT)
- Tirol Kliniken (AT)
- Klinikum Wels-Grieskirchen (AT)
- Krankenhaus der Elisabethinen (AT)
- MAS Alzheimerhilfe (AT)
- Schwarzwald-Baar Klinikum (DE)
- LungenClinic Grosshansdorf (DE)
- Karl Landsteiner University of Health Sciences (AT)
- Medical University of Vienna (AT)
Publication Details
- Journal
- Wiener klinische Wochenschrift
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1007/s00508-025-02521-x
- Citations
- 2
- Primary Topic
- Erythropoietin and Anemia Treatment
- Type
- article
- Field-Weighted Citation Impact
- 3.54