Endoplasmic Reticulum Stress Drives Neuroinflammation Through Lipocalin 2 Upregulation in Retinal Microglia After Optic Nerve Injury
This study elucidates the critical role of LCN2 in linking ER stress and inflammation in ONI, offering a promising therapeutic target. AAV-mediated Lcn2 silencing outperforms broad ER stress inhibition, providing a novel strategy for treating optic nerve injuries.
Authors
- Yujun Ma (ORCID: https://orcid.org/0000-0002-0577-959X)
- Jiahe Nie
- Jinmiao Li (ORCID: https://orcid.org/0000-0002-5130-4616)
- Hongwei Zhang (ORCID: https://orcid.org/0000-0002-2288-5394)
- Xinyue Wang (ORCID: https://orcid.org/0000-0002-1134-9174)
- Yizhi Liu (ORCID: https://orcid.org/0000-0003-4108-9593)
- Junjie Tang (ORCID: https://orcid.org/0000-0003-3185-9929)
- Weifeng Huang (ORCID: https://orcid.org/0000-0003-3616-2880)
- Siuhang Yip
- Yang Gao (ORCID: https://orcid.org/0000-0001-5536-3931)
- Rong Lu
- Shicai Su
Institutions
- Sun Yat-sen University (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-05-06
- DOI
- https://doi.org/10.1167/iovs.66.5.12
- Citations
- 7
- Primary Topic
- Neurological Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 5.90