Natural history of the revised ALS functional rating scale and its association with survival: the PRECISION-ALS Extant Study
Functional loss in ALS follows a decelerating trajectory, where the current functional status and the rate of change have a direct impact on the patient' s probability of survival. Given the pivotal role of the ALSFRS-R in drug development, these results help to separate treatment benefit from the disease's natural trajectory and to estimate the impact on survival.
Authors
- Carlos Pastor‐Vargas (ORCID: https://orcid.org/0000-0002-4678-7967)
- Philip Van Damme (ORCID: https://orcid.org/0000-0002-4010-2357)
- Miriam Galvin (ORCID: https://orcid.org/0000-0002-8232-8020)
- Mark Heverin (ORCID: https://orcid.org/0000-0002-7326-4432)
- Fouke Ombelet (ORCID: https://orcid.org/0000-0003-1530-0869)
- Nikita Lamaire
- Christopher J. McDermott (ORCID: https://orcid.org/0000-0002-1269-9053)
- Sarah Opie-Martin (ORCID: https://orcid.org/0000-0003-0951-8589)
- Ruben P. A. van Eijk (ORCID: https://orcid.org/0000-0002-7132-5967)
- Umberto Manera (ORCID: https://orcid.org/0000-0002-9995-8133)
- Caroline Ingre (ORCID: https://orcid.org/0000-0001-5327-7204)
- Harry McDonough
- Rosario Vasta (ORCID: https://orcid.org/0000-0002-0393-4736)
- Leonard H. van den Berg (ORCID: https://orcid.org/0000-0002-5203-9674)
- Jordi W. J. van Unnik (ORCID: https://orcid.org/0000-0002-3238-6740)
- Stefan Sennfält (ORCID: https://orcid.org/0000-0002-7114-2757)
- Robert McFarlane (ORCID: https://orcid.org/0000-0001-7380-4219)
- Pamela J. Shaw (ORCID: https://orcid.org/0000-0002-8925-2567)
- Éanna Mac Domhnaill (ORCID: https://orcid.org/0009-0001-1197-9950)
- Daphne N. Weemering (ORCID: https://orcid.org/0009-0005-4182-3294)
- Frederik Hobin (ORCID: https://orcid.org/0009-0005-2167-5896)
- Philippe Corcia
- Jan H. Veldink
- Adriano Chiò
- Mónica Povedano Panadés
- Alejandro Caravaca Puchades
- Oskar Holmdahl
- Mohammed Mouzouri
Institutions
- Université de Tours (FR)
- Karolinska University Hospital (SE)
- Inserm (FR)
- King's College London (GB)
- Trinity College Dublin (IE)
- Bellvitge University Hospital (ES)
- Karolinska Institutet (SE)
- University Medical Center Utrecht (NL)
- Institut d'Investigació Biomédica de Bellvitge (ES)
- Centre Hospitalier Universitaire de Tours (FR)
- Laboratoire National de Référence (MA)
- Neuroscience Institute (IT)
- King's College Hospital (GB)
- VIB-KU Leuven Center for Brain & Disease Research (BE)
- University of Turin (IT)
- Oklahoma State University Center for Health Sciences (US)
- University of Sheffield (GB)
- KU Leuven (BE)
Publication Details
- Journal
- Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
- Published
- 2025-05-06
- DOI
- https://doi.org/10.1080/21678421.2024.2443985
- Citations
- 5
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 6.95
Funders
- Biogen
- Motor Neurone Disease Research Institute of Australia
- South London and Maudsley NHS Foundation Trust
- MND Scotland
- LifeArc
- National Institute for Health and Care Research
- Motor Neurone Disease Association
- King's College London
- Fonds Wetenschappelijk Onderzoek
- KU Leuven
- Vlaamse regering
- Medical Research Council