The AAHKS Surgical Techniques and Technologies Award: Synovial Fluid Metal Ion Levels as a Biomarker for Aseptic Loosening Following Cemented Total Knee Arthroplasty: A Prospective Study
Aseptic loosening remains a challenging diagnosis without an available confirmatory test. Although the current sample size is limited, our results indicate that synovial fluid cobalt and zirconium levels are valuable indicators of component loosening. In the absence of definitive X-ray findings, synovial fluid analysis offers a promising diagnostic modality. This test can potentially improve patient outcomes by enabling earlier and more accurate detection of aseptic loosening following primary cemented TKA.
Authors
- J Ryan Martin (ORCID: https://orcid.org/0000-0002-4125-2154)
- Stephen M. Engstrom
- Aleksander P. Mika (ORCID: https://orcid.org/0000-0002-5260-4506)
- Gregory G. Polkowski (ORCID: https://orcid.org/0000-0002-8990-7578)
- Jacob M. Wilson (ORCID: https://orcid.org/0000-0002-5044-7084)
- Jeroen L. A. Pennings (ORCID: https://orcid.org/0000-0002-9188-6358)
- Courtney E. Baker (ORCID: https://orcid.org/0000-0002-4088-2947)
Institutions
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- The Journal of Arthroplasty
- Published
- 2025-05-06
- DOI
- https://doi.org/10.1016/j.arth.2025.04.067
- Citations
- 3
- Primary Topic
- Orthopaedic implants and arthroplasty
- Type
- article
- Field-Weighted Citation Impact
- 6.02
Funders
- Georgia Clinical and Translational Science Alliance
- American Association of Hip and Knee Surgeons
- National Institutes of Health
- National Center for Advancing Translational Sciences