Combining ATAC-seq and RNA-seq reveals key genes for gonadal abnormalities in one-month-old XX-DSD pigs
This study elucidates the critical regulatory role of specific open chromatin structures in the SOX9 gene promoter region (8647563-8648475) in gonadal development of XX-DSD pigs. Additionally, we identify that genes such as SOX9, HSD3B1, and CYP19A1 act in concert to participate in gonadal development. These findings provide molecular evidence for the dynamic chromatin regulatory network underlying gonadal dysgenesis in XX-DSD and lay the foundation for subsequent mechanistic studies.
Authors
- Haiyi Yu (ORCID: https://orcid.org/0000-0003-0761-5270)
- Yuqiao Zhang
- Bingzhou Zhong
- Hua Li (ORCID: https://orcid.org/0000-0003-2153-2500)
- Hui Yu
- Jinhua Wu (ORCID: https://orcid.org/0000-0002-8511-3949)
- Congying Yu
- Haiquan Zhao
Institutions
- Foshan University (CN)
- The University of Western Australia (AU)
- Zhongshan Hospital (CN)
Publication Details
- Journal
- BMC Genomics
- Published
- 2025-05-06
- DOI
- https://doi.org/10.1186/s12864-025-11613-x
- Citations
- 1
- Primary Topic
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Type
- article
- Field-Weighted Citation Impact
- 1.82
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province